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Wanek School of Natural Sciences
Biology

Angela Bauer

Professor and Chair of Biology

 

Research in my laboratory focuses on the potential health effects of exposure to endocrine disruptors. Endocrine disruptors are chemicals within our environment (e.g. components of plastics, pesticides, herbicides, pharmaceutical contaminants in groundwater, hormones in dairy manure) that interfere with hormone signaling once they enter the body. Many endocrine disruptors mimic or block the actions of the sex hormones, estrogens and androgens. Thus, physiological processes that are known to be regulated by our endogenous sex hormones (e.g. sexual differentiation, reproduction, bone ossification) are susceptible to disruption by these chemicals. Furthermore, the incidence and progression of certain diseases that are hormone sensitive (e.g. endometriosis, breast cancer, prostate cancer, inter-sexed conditions) are suspected to be influenced by exposure to endocrine disruptors.

Currently, two lines of research that focus on endocrine disruption are underway in my laboratory. They include 1) an assessment of the ability of plant estrogens (e.g., EGCG, a component of green tea) to mitigate or block the proliferative effects of estrogenic endocrine disruptors on breast cancer cells; and 2) an examination of the impact of estrogenic endocrine disruptors on skeletal development in zebrafish.

In addition to conducting scientific research on the negative health effects of exposure to environmental endocrine disruptors, I also conduct research in the field of the Scholarship of Teaching and Learning (SoTL). My specific SoTL interests include the impact of active learning strategies on academic performance and engagement within the science classroom (in both general education courses for nonmajors and upper level courses for majors), the benefits of the flipped classroom for providing opportunities that foster deep disciplinary learning within the sciences, and inclusive classroom practices that close the opportunity gap between majority and underrepresented students in the sciences.

 

PUBLICATIONS (JOURNAL ARTICLES, BOOK CHAPTERS, CONFERENCE PROCEEDINGS)

Bauer, A.C. and Haynie, A. (in press). Does the Flipped Classroom Foster Deep Disciplinary Learning? In Big Picture Pedagogies, R.A.R. Gurung and D. Voelker, editors. Jossey-Bass,Wiley, San Francisco, CA.

Baker, K.M. and Bauer, A.C. (2015): Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells. International Journal of Breast Cancer, Volume 2015, Article 163591, 7 pages. doi:10.1155/2015/163591.

Bauer, A.C. (2015): The Two-Sex System: Fact or Fallacy? American Association of Colleges and Universities (AAC&U) Scientific Thinking and Integrative Reasoning Skills (STIRS) Case Studies. http://www.aacu.org/stirs/casestudies/bauer .

Bauer, A.C., Wingert, S., Fermanich, K.J., and Zorn, M.E. (2013). Well Water in Karst Regions of Northeast Wisconsin Contains Estrogenic Factors, Nitrate and Bacteria. Water Environment Research 85(40): 318-326.

Bauer-Dantoin, A.C. (2012): Modern Day Agricultural Practices and Their Impact on Human Health and the Environment. The Praeger Handbook of Environmental Health, Robert Friis, Editor, Volume 4 (pp. 527-550).

Bauer-Dantoin, A.C. and Meinhardt, D. (2010): 17-Estradiol Exposure Accelerates Skeletal Development in Xenopus laevis Tadpoles. The Anatomical Record 293(11): 1880-1886.

Bauer-Dantoin, A.C. (2008): The Evolution of Scientific Teaching Within the Biological Sciences. In Exploring Signature Pedagogies: Approaches to Teaching Disciplinary Habits of Mind. R.A.R. Gurung, N.L. Chick, and A. Haynie, editors. Stylus Publishing LLC, Sterling, VA.

Bauer-Dantoin, A.C. (2008): Using service learning in a course entitled Biology of Women to promote student engagement and awareness of community needs and resources. Bioscene, Journal of College Biology Teaching 34(1): 13-19.

Bauer-Dantoin A.C. (2007): Impact of a course entitled Ethnic Minorities in Science on students’ attitudes toward race and their awareness of diversity issues in the sciences. Proceedings from the second biennial conference of Innovations in the Scholarship of Teaching and Learning at the Liberal Arts Colleges.

Bauer-Dantoin, A.C. and Hanke, C.J. (2007): Using a classic paper by I. E. Lawton and N. B. Schwartz to consider the array of factors that control luteinizing hormone production. Advances in Physiology Education 31: 318-322.

Hanke, C.J. and Bauer-Dantoin, A.C. (2006): Teaching aldosterone regulation and basic scientific principles using a classic paper by Dr. James O. Davis and colleagues. Advances in Physiology Education 30: 141-144.

Bauer-Dantoin, A.C. and Ritch, D. (2006): Moving beyond the “add and stir” approach to increasing diversity in the sciences: Design and implementation of an undergraduate course entitled Ethnic Minorities in Science. Journal of Women and Minorities in Science and Engineering 11: 329-343.

Splett, C.L., Scheffen, J.R., Desotelle, J.A., Plamann, V. and Bauer-Dantoin, A.C. (2003): Galanin Enhancement of Gonadotropin-Releasing Hormone (GnRH)-Stimulated Luteinizing Hormone (LH) Secretion in Female Rats is Estrogen-Dependent: Evidence for a Direct Pituitary Role for Galanin in the Generation of Preovulatory LH Surges. Endocrinology 144(2): 484- 490.

Scheffen, J.R., Splett, C.L., Desotelle, J.A., and Bauer-Dantoin, A.C. (2003): Testosterone-Dependent Effects of Galanin on Pituitary Luteinizing Hormone Secretion in Male Rats. Biology of Reproduction 68(2): 363-369.

Bauer-Dantoin, A.C. (2001): Incorporating Techniques of Molecular Genetics into the Developmental Biology Laboratory Curriculum: Modeling the Current State of the Field. Bioscene, Journal of College Biology Teaching, Volume 27(2): 3-11.

Sundaresan, S., Weiss, J., Bauer-Dantoin, A.C. and Jameson, J.L. (1997): Expression of ryanodine receptors in the pituitary gland: Evidence for a role in GnRH signaling. Accepted for publication in Endocrinology 138(5): 2056‑65.

Besecke, L.M., Guendner, M.J., Schneyer, A.L., Bauer-Dantoin, A.C., Jameson, J.L. and Weiss, J. (1996): GnRH regulates FSHβ gene expression through an activin/follistatin autocrine or paracrine loop. Endocrinology 137: 3667-3673.

Colin, I.M., Bauer-Dantoin, A.C., Sundaresan, S., Kopp, P. and Jameson, J.L. (1996): Sex-dependent transcriptional responses to GnRH require chronic in vivo exposure to estradiol. Endocrinology 137: 2300-2307.

Bauer-Dantoin, A.C., Weiss, J. and Jameson, J.L. (1996): Gonadotropin-releasing hormone regulation of pituitary follistatin gene expression during the primary FSH surge. Endocrinology 137: 1634-1639.

Bauer-Dantoin, A.C. and Jameson, J.L. (1995): Gonadotropin-releasing hormone receptor messenger ribonucleic acid expression in the ovary during the rat estrous cycle. Endocrinology 136: 4432-4438.

Bauer-Dantoin, A.C., Weiss, J., and Jameson, J.L. (1995): Roles of estrogen, progesterone and gonadotropin-releasing hormone (GnRH) in the control of pituitary GnRH receptor gene expression at the time of the preovulatory gonadotropin surges. Endocrinology 136 (3): 1014-1019.

Knox, K.L., Bauer-Dantoin, A.C., Levine, J.E., and Schwartz, N.B. (1995): Unmasking of the inhibitory effects of neuropeptide Y on in vitro gonadotropin secretion from pituitaries of metestrous but not proestrous rats. Endocrinology 136(1): 187-194.

Halvorson, L.M., Weiss, J., Bauer-Dantoin, A.C., and Jameson, J.L. (1994) : Dynamic regulation of pituitary follistatin messenger RNAs during the rat estrous cycle. Endocrinology 134(3): 1247-1253.

Bauer-Dantoin, A.C., Hollenberg, A.N., and Jameson, J.L. (1993): Dynamic regulation of GnRH receptor mRNA levels in the anterior pituitary gland during the rat estrous cycle. Endocrinology 133(4): 1911-1914.

Bauer-Dantoin, A.C., Tabesh, B., Norgle, J.R., and Levine, J.E. (1993): RU486 blocks NPY potentiation of LHRH-induced LH surges in proestrous rats. Endocrinology 133(6): 2418-2423.

Bauer-Dantoin, A.C., Knox, K.L., Schwartz, N.B., and Levine, J.E. (1993): Estrous cycle stage-dependent effects of NPY on LHRH-stimulated LH and FSH secretion from anterior pituitary fragments in vitro. Endocrinology 133(6): 2413-2417.

Urban, J.H., Bauer-Dantoin, A.C., and Levine, J.E. (1993): NPY gene expression in the arcuate nucleus: Sexual dimorphism and modulation by testosterone. Endocrinology 132(1): 139-145.

Bauer-Dantoin, A.C., Urban, J.H., and Levine, J.E. (1992): NPY gene expression in the arcuate nucleus is increased during preovulatory LH surges. Endocrinology 131(6): 2953-2958.

Bauer-Dantoin, A.C., McDonald, J.K., and Levine, J.E. (1992): NPY potentiates LHRH-induced LH secretion only under conditions leading to preovulatory LH surges. Endocrinology 131(6): 2946-2952.

Bauer-Dantoin, A.C., McDonald, J.K., and Levine, J.E. (1991): NPY enhances LHRH-stimulated LH surges in pentobarbital-blocked proestrous rats. Endocrinology 129(1): 402-408.

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