The development and dispersal of bacterial antibiotic resistance is an international public health crisis. Students in my lab are investigating the potential for commonly-prescribed pharmaceuticals to act synergistically with existing antibiotic compounds. These projects have the potential to describe novel combination therapies that could serve as new tools in our fight against antibiotic-resistant microbes.
Vigueira P., McCommis K.S., Schweitzer G., Remedi M.S., Chambers K.T., Fu X., McDonald W.G., Cole S., Colca J.R., Kletzien R.K., Burgess S.C., Finck B.N., 2014. Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion. Cell Reports 7, 2042-2053: 10.1016/j.celrep.2014.05.017.
Vigueira, P., Ray, S.S., Martin, B., Ligon, M., Paul, K.S., 2012. Effects of the Green Tea Catechin (-)-epigallocatechin gallate on Trypanosoma brucei. International Journal for Parasitology: Drugs and Drug Resistance, 2 (2012) 225-229.
Chen, Z., Vigueira, P., Chambers, K.T., Hall, A.M., Mitra, M.S., McDonald,W.G., Colca, J.R., Kletzien, R.F., Finck, B.N., 2012. A PPARγ-sparing Thiazolidinedione Ameliorates Hepatic Insulin Resistance and Metabolic Dysfunction in Diet-Induced Obese Mice. The Journal of Biological Chemistry, 287(28): 23537-48.
Vigueira, P., Paul, K.S., 2012. Trypanosoma brucei: Inhibition of Acetyl-CoA Carboxylase by Haloxyfop. Experimental Parasitology, 130(2): 159-165.
Vigueira, P., Paul, K.S., 2011. Requirement for Acetyl-CoA Carboxylase in Trypanosoma brucei is Dependent Upon the Growth Environment. Molecular Microbiology, 80(1): 117-132.