Wanek School of Natural Sciences

Patrick Vigueira

The development and dispersal of bacterial antibiotic resistance is an international public health crisis. Students in my lab are investigating the potential for commonly-prescribed pharmaceuticals to act synergistically with existing antibiotic compounds. These projects have the potential to describe novel combination therapies that could serve as new tools in our fight against antibiotic-resistant microbes.

Selected Publications:

Vigueira P., McCommis K.S., Schweitzer G., Remedi M.S., Chambers K.T., Fu X., McDonald W.G., Cole S., Colca J.R., Kletzien R.K., Burgess S.C., Finck B.N., 2014. Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion. Cell Reports 7, 2042-2053: 10.1016/j.celrep.2014.05.017.

Vigueira, P., Ray, S.S., Martin, B., Ligon, M., Paul, K.S., 2012. Effects of the Green Tea Catechin (-)-epigallocatechin gallate on Trypanosoma brucei. International Journal for Parasitology: Drugs and Drug Resistance, 2 (2012) 225-229.

Chen, Z., Vigueira, P., Chambers, K.T., Hall, A.M., Mitra, M.S., McDonald,W.G., Colca, J.R., Kletzien, R.F., Finck, B.N., 2012. A PPARγ-sparing Thiazolidinedione Ameliorates Hepatic Insulin Resistance and Metabolic Dysfunction in Diet-Induced Obese Mice. The Journal of Biological Chemistry, 287(28): 23537-48.

Vigueira, P., Paul, K.S., 2012. Trypanosoma brucei: Inhibition of Acetyl-CoA Carboxylase by Haloxyfop. Experimental Parasitology, 130(2): 159-165.

Vigueira, P., Paul, K.S., 2011. Requirement for Acetyl-CoA Carboxylase in Trypanosoma brucei is Dependent Upon the Growth Environment. Molecular Microbiology, 80(1): 117-132.

Biology at HPU


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