Jwala Renukuntla PhD

Dr. Jwala Renukuntla received her Bachelor of Pharmacy degree from JSS University, India. She then received her PhD in Pharmaceutics from the Department of Pharmaceutical Sciences at the University of Missouri Kansas City-School of Pharmacy (UMKC-SOP). After mastering skills in Pharmaceutics and its application to drug delivery, she started her career as an Assistant professor of Pharmaceutics at the South College School of Pharmacy, Knoxville, TN. Her primary research focus is to develop nanotechnology-based drug delivery systems to treat Ocular Infections. She successfully obtained external funding from International Academy of Compounding Pharmacy (IACP) to study the stability of Compounded pain medication cream. Later she moved to the University of Texas El Paso School of Pharmacy where she established her Drug Delivery research lab and secured extramural funding from Pharmaceutical industry and several pilot project Grants. She published her research in multiple Pharmaceutics and drug delivery journals and she also published several book chapters. She presented her work at prestigious conferences like Controlled Release Society meeting, Gordon Research Conference and American Association of Pharmaceutical Sciences. Currently she is working as an Associate Professor of Pharmaceutics at the Fred Wilson School of Pharmacy, Department of Basic Pharmaceutical Sciences at High Point University, where she heads a lab that specializes in nanotechnology-based drug delivery systems to treat Ocular and skin infections. Her other research interests are non-sterile compounding and sterile compounding and stability testing.

Published Articles
Bolla, P.K.; Meraz, C.A.; Rodriguez, V.A.; Deaguero, I.; Singh, M.; Yellepeddi, V.K.;Renukuntla,J*. Clotrimazole Loaded Ufosomes for Topical Delivery: Formulation Development and In-Vitro Studies. Molecules 2019,24,3139. (* Corresponding Author)
Rodriguez, V.A.; Bolla, P.K.; Kalhapure, R.S.; Boddu, S.H.S.; Neupane, R.; Franco, J.; Renukuntla,J*. Preparation and Characterization of Furosemide-Silver Complex Loaded Chitosan Nanoparticles. Processes 2019,7,206. (* Corresponding Author)
Kalhapure, R.S.; Bolla, P.K.; Boddu, S.H.; Renukuntla,J*. Evaluation of Oleic Acid and Polyethylene Glycol Monomethyl Ether Conjugate (PEGylated Oleic Acid) as a Solubility Enhancer of Furosemide. Processes 2019,7,520. (* Corresponding Author)
Chen J, Jiang S, Wang J, Renukuntla J, Sirimulla S,”Chen J. A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism. Drug Metab Rev. 2019 May;51(2):178-195. doi: 10.1080/03602532.2019.1632889. Epub 2019 Jun 28.
Daftardar S”, Neupane R, Boddu SH, Renukuntla J. Tiwari A. Advances in Ultrasound Mediated Transdermal Drug Delivery, Current Pharmaceutical Design,2019 doi: 10.2174/1381612825666190211163948
Pradeep Kumar Bolla, Rahul S. Kalhapure, Victor A. Rodriguez, David V. Ramos, Amit Dahl, Jwala Renukuntla*. Preparation of solid lipid nanoparticles of furosemide-silver complex and evaluation of antibacterial activity. Journal of Drug Delivery Science and Technology, 2019,49,6-13. (* Corresponding Author)
Rahul S. Kalhapure and Jwala Renukuntla*. Thermo- and pH dual responsive polymeric nanosystems. Chemico-Biological Interactions, 2018, 295,20-37. (* Corresponding Author)
Pradeep Kumar Bolla, Victor A Rodriguez, Rahul S Kalhapure, Chandra Sekhar Kolli, Sweta Andrews,”Jwala Renukuntla*. A review on pH and temperature responsive gels and other less explored drug delivery systems. Journal of Drug Delivery Science and Technology. 2018; 46: 416-435. (* Corresponding Author)
Rahul Kalhapure“, Pradeep Kumar Bolla, Delfina Dominguez, Amit Dahl, Sai Boddu, Jwala Renukuntla*, Furosemide-silver complex nanosuspension: preparation and evaluation of antibacterial activity Source: IET nanobiotechnology,2018,”12 (6): 836-840. DOI: 1049/iet-nbt.2017.0284 (* Corresponding Author)
Kalhapure RS”, Jadhav M, Rambharose S, Mocktar C, Singh S, Renukuntla J, Govender, T. pH-responsive chitosan nanoparticles from a novel twin-chain anionic amphiphile for controlled and targeted delivery of vancomycin. Colloids and Surfaces B: Biointerfaces,2017 Oct 1;158:650-657.
Kalhapure RS,”Sikwal DR“,”Rambharose S“,”Mocktar C“,”Singh S“,”Bester L“,”Oh JK“, Renukuntla J,”Govender T. Enhancing targeted antibiotic therapy via pH responsive solid lipid nanoparticles from an acid cleavable lipid. Nanomedicine“,2017 Aug;13(6):2067-2077.
Renukuntla J, Vadlapudi A, Boddu SHS, Patel A, Mitra AK, Approaches for enhancing the oral bioavailability of proteins and peptides, International Journal of Pharmaceutics,2013 Apr 15;447(1-2):75-93
Boddu SHS, Vaishya R, Jwala J, Vadlapudi A, Pal D,Mitra AK. Preparation and Characterization of Folate Conjugated Nanoparticles of Doxorubicin using PLGA-PEG-FOL Polymer. Medicinal chemistry. 2012; 2:68-75
Jwala J, Vadlapatla R, Vadlapudi A, Boddu SHS, Pal DJ, Mitra AK. Differential expression of folate receptor-alpha (FR-α),sodium dependent multivitamin transporter (SMVT) and amino acid transporter (B (0,+)) in human retinoblastoma (Y-79) and retinal pigment epithelial (ARPE-19) cell lines. Journal of Ocular Pharmacology and Therapeutics. 2012; 28(3):237-44
Jwala J, Boddu SHS, Paturi DK, Shah S, Smith SB, Pal D, et al. Functional characterization of folate transport proteins in staten’s seruminstitut rabbit corneal epithelial cell line. Current Eye Research,2011; 36(5):404-16
Jwala J, Boddu SHS, Shah S, Sirimulla S, Pal D,Mitra AK. Ocular sustained release nanoparticles containing stereo isomeric dipeptide prodrugs of acyclovir. Journal of Ocular Pharmacology and Therapeutics. 2011; 27(2):163-72
Boddu SHS, Jwala J, Chowdhury MR, Mitra AK. In vitro evaluation of a targeted and sustained release system for retinoblastoma cells using doxorubicin as a model drug. Journal of Ocular Pharmacology and Therapeutics,2010; 26(5):459- 68
Earla R, Boddu SHS, Cholkar K, Hariharan S, Jwala J,Mitra AK. Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoids-quantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2010,Aug 1;52(4):525-33
Mishra GP, Tamboli VM, Jwala J, Mitra AK. Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. Recent Patents on Inflammation & Allergy Drug Discovery,2011; 5(1):26-36
Gaudana R, Jwala J, Boddu SH, Mitra AK. Recent perspectives in ocular drug delivery,Pharmaceutical research. 2010; 26(5):1197-1216
Boddu SH, Jwala J, Vaishya R, Earla R, Karla PK, Pal D,Mitra AK 2010. Novel nanoparticulate gel formulations of steroids the treatment of macular edema,Journal of Ocular Pharmacology Therapeutics. 26(1):37-48
Book Chapters
Bahl Dhreya, Bachu Rinda Devi, Chitti Mrudula, Chowdhury Pallabita, Renukuntla Jwala, Boddu SHS. Transscleral Iontophoretic Drug Delivery for Treating Retinal Diseases. ln: Drug Delivery for the Retina and Posterior Segment Disease,published by Springer. 2018,ISBN:978-3-319-95806-4.
Boddu SHS, Renukuntla J, Riga A, Alexander K. Excipients as Active Pharmaceutical Ingredients, Drug Delivery Applications of Excipients, edited by Narang A,Boddu SHS and published by Springer. 2015,Pages 613-636.
Chandrasekhar Garapati, Himanshu Gupta, Jwala Renukuntla and Sai H. S. Boddu. Tailoring the Release of Drugs Using Excipients, published by Springer edited by Narang A,Boddu SHS and published by Springer. 2015
Renukuntla J, Sujay J. Shah, Aswani Dutt Vadlapudi, Mitesh Patel and Ashim Mitra. Drug Delivery to Anterior Segment of the Eye, Treatise on Ocular Drug Delivery,edited by Mitra AK and published by Bentham Science. (ISBN# 978-1-60805-175-5,2013)
Mitesh Patel, Megha Barot, Jwala Renukuntla and Ashim K. Mitra. Protein and Peptide Drug Delivery, Advanced Drug Delivery, edited by Ashim K. Mitra, Chi H. Lee, Kun Cheng and published by John Wiley & Sons,Inc. ISBN: 978-1-118-02266-5,2013
Gunda S, Boddu SHS, Gupta J, Mitra AK, Ocular Pharmacokinetics: Challenges and Models, In: Duane’s Foundations of Clinical Ophthalmology,2012,J. B. Lippincott Co. p. 17337-17350,2012
Kwatra D, Gaudana R, Vaishya R, Jwala J, Mitra A.K, “Ocular delivery using prodrugs”, Methods and Principles in Medicinal Chemistry, Wiley- VCH Verlag GmbH & Co. KGaA,2012
Boddu SH, Jwala J, Janoria KG, Pal D, and Mitra AK, Development of Steroid-Nanoparticles for the Treatment of Macular Edema,J Interdisciplinary Research.Vol 2,No 1, Megan Cornell (Ed), KCMO,81-99,2008.
Awarded Grants
Development of Transdermal Nano formulations of Fluosterone
Role: PI
Awarding Agency: Sterotherapeutic Inc.,226821180A.
Fund: $25,000 (December 14,2017 – May 31,2018)
Development of Transdermal Nano formulations of Nicotine loaded solid lipid nanoparticles
Role: PI
Awarding agency: Paso Del Norte Health Foundation,226811487A. (Internal Grant
Fund: $30,000.00 (December 1,2017 – August 1,2019)
Can pH-responsive nano-antibiotics control the antibacterial resistance crisis
Role: PI
Awarding Agency: UTEP Border Biomedical Research Center (BBRC) NIH Pilot grant
Fund: $33,000.00 (May 15,2018 – May 15,2019)
Acquisition of a microfluidic-based 3D bio printer for additive manufacturing of biomaterials for fabrication of tissue-on-a-chip models
Major Research Instrument Grant
Awarding Agency: National Science Foundation (NSF)
Fund:  $380,000
Role: Collaborator
Extension of Beyond the Use Dates (BUD) for Combination Topical Pain Medications
Awarding Agency: International Academy of Compounding Pharmacists (IACP)
Fund: $10,0000 (7/01/2013 – 01/01/2015)